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Lysosomes Rewrite the Epigenome to Pass Longevity Signals Across Generations

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Peter Attia Builds a Practical Framework for Getting Real Value From Genetic Tests

Peter Attia Builds a Practical Framework for Getting Real Value From Genetic Tests

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Insomnia Makes Older Adults 3x More Vulnerable to Inflammation-Triggered Depression

Insomnia Makes Older Adults 3x More Vulnerable to Inflammation-Triggered Depression

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Treating Hearing Loss May Slow Cognitive Decline in Older Adults

Treating Hearing Loss May Slow Cognitive Decline in Older Adults

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Flu and COVID-19 Can Awaken Dormant Breast Cancer Cells in the Lungs

Flu and COVID-19 Can Awaken Dormant Breast Cancer Cells in the Lungs

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How to Control Aggression Using Neuroscience and Simple Daily Tools

How to Control Aggression Using Neuroscience and Simple Daily Tools

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Cochrane Review Confirms Convalescent Plasma Fails to Cut COVID-19 Mortality

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Ultra-Processed Foods Raise Heart Disease Risk by Up to 65%, Major European Report Finds

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Dr. Kentaro Fujita Reveals the Science of Self-Control and Beating Procrastination

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Naked Mole Rat Longevity Gene Transferred to Mice Extends Their Lifespan

Naked Mole Rat Longevity Gene Transferred to Mice Extends Their Lifespan

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HDAC Inhibitor Plus Checkpoint Blocker Tested in Advanced Lung Cancer Trial

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Low-Dose Ipilimumab Plus Pembrolizumab Targets Melanoma Brain Metastases

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FDA Grants Expanded Approval to Zongertinib for HER2-Mutant Lung Cancer

FDA Grants Expanded Approval to Zongertinib for HER2-Mutant Lung Cancer

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FDA Approves Four Neurological Drugs Targeting Alzheimer's, Glioma, and Rare Disease

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Centenarians Defy Immune Aging Through Unique Inflammatory Control Mechanisms

Centenarians Defy Immune Aging Through Unique Inflammatory Control Mechanisms

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Why Some 80-Year-Olds Have the Memory of 50-Year-Olds — Scientists Finally Explain

Why Some 80-Year-Olds Have the Memory of 50-Year-Olds — Scientists Finally Explain

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Anti-Amyloid Alzheimer's Drugs Show Trivial Cognitive Benefit With Real Brain Bleed Risk

Anti-Amyloid Alzheimer's Drugs Show Trivial Cognitive Benefit With Real Brain Bleed Risk

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FDA Approves Zongertinib for HER2-Mutant Lung Cancer in Landmark Targeted Therapy Win

FDA Approves Zongertinib for HER2-Mutant Lung Cancer in Landmark Targeted Therapy Win

Drug Approval·

April 20, 2026

Peter Attia Builds a Practical Framework for Getting Real Value From Genetic Tests

Peter Attia Builds a Practical Framework for Getting Real Value From Genetic Tests

Podcast·

May 18, 2026

Insomnia Makes Older Adults 3x More Vulnerable to Inflammation-Triggered Depression

Insomnia Makes Older Adults 3x More Vulnerable to Inflammation-Triggered Depression

Paper·

May 17, 2026

Treating Hearing Loss May Slow Cognitive Decline in Older Adults

Treating Hearing Loss May Slow Cognitive Decline in Older Adults

Trial·

May 16, 2026

Flu and COVID-19 Can Awaken Dormant Breast Cancer Cells in the Lungs

Flu and COVID-19 Can Awaken Dormant Breast Cancer Cells in the Lungs

Paper·

May 15, 2026

How to Control Aggression Using Neuroscience and Simple Daily Tools

How to Control Aggression Using Neuroscience and Simple Daily Tools

Podcast·

May 15, 2026

Cochrane Review Confirms Convalescent Plasma Fails to Cut COVID-19 Mortality

Cochrane Review Confirms Convalescent Plasma Fails to Cut COVID-19 Mortality

Review·

May 13, 2026

Ultra-Processed Foods Raise Heart Disease Risk by Up to 65%, Major European Report Finds

Ultra-Processed Foods Raise Heart Disease Risk by Up to 65%, Major European Report Finds

Press·

May 12, 2026

Dr. Kentaro Fujita Reveals the Science of Self-Control and Beating Procrastination

Dr. Kentaro Fujita Reveals the Science of Self-Control and Beating Procrastination

Podcast·

May 12, 2026

Naked Mole Rat Longevity Gene Transferred to Mice Extends Their Lifespan

Naked Mole Rat Longevity Gene Transferred to Mice Extends Their Lifespan

Press·

May 11, 2026

HDAC Inhibitor Plus Checkpoint Blocker Tested in Advanced Lung Cancer Trial

HDAC Inhibitor Plus Checkpoint Blocker Tested in Advanced Lung Cancer Trial

Trial·

May 7, 2026

Low-Dose Ipilimumab Plus Pembrolizumab Targets Melanoma Brain Metastases

Low-Dose Ipilimumab Plus Pembrolizumab Targets Melanoma Brain Metastases

Trial·

May 7, 2026

FDA Grants Expanded Approval to Zongertinib for HER2-Mutant Lung Cancer

FDA Grants Expanded Approval to Zongertinib for HER2-Mutant Lung Cancer

Drug Approval·

May 6, 2026

FDA Approves Four Neurological Drugs Targeting Alzheimer's, Glioma, and Rare Disease

FDA Approves Four Neurological Drugs Targeting Alzheimer's, Glioma, and Rare Disease

Drug Approval·

May 5, 2026

Centenarians Defy Immune Aging Through Unique Inflammatory Control Mechanisms

Centenarians Defy Immune Aging Through Unique Inflammatory Control Mechanisms

Review·

April 28, 2026

Why Some 80-Year-Olds Have the Memory of 50-Year-Olds — Scientists Finally Explain

Why Some 80-Year-Olds Have the Memory of 50-Year-Olds — Scientists Finally Explain

Press·

April 24, 2026

Anti-Amyloid Alzheimer's Drugs Show Trivial Cognitive Benefit With Real Brain Bleed Risk

Anti-Amyloid Alzheimer's Drugs Show Trivial Cognitive Benefit With Real Brain Bleed Risk

Review·

April 20, 2026

FDA Approves Zongertinib for HER2-Mutant Lung Cancer in Landmark Targeted Therapy Win

FDA Approves Zongertinib for HER2-Mutant Lung Cancer in Landmark Targeted Therapy Win

Drug Approval·

April 20, 2026

Peter Attia Builds a Practical Framework for Getting Real Value From Genetic Tests

Peter Attia Builds a Practical Framework for Getting Real Value From Genetic Tests

Podcast·

May 18, 2026

Insomnia Makes Older Adults 3x More Vulnerable to Inflammation-Triggered Depression

Insomnia Makes Older Adults 3x More Vulnerable to Inflammation-Triggered Depression

Paper·

May 17, 2026

Treating Hearing Loss May Slow Cognitive Decline in Older Adults

Treating Hearing Loss May Slow Cognitive Decline in Older Adults

Trial·

May 16, 2026

Flu and COVID-19 Can Awaken Dormant Breast Cancer Cells in the Lungs

Flu and COVID-19 Can Awaken Dormant Breast Cancer Cells in the Lungs

Paper·

May 15, 2026

How to Control Aggression Using Neuroscience and Simple Daily Tools

How to Control Aggression Using Neuroscience and Simple Daily Tools

Podcast·

May 15, 2026

Cochrane Review Confirms Convalescent Plasma Fails to Cut COVID-19 Mortality

Cochrane Review Confirms Convalescent Plasma Fails to Cut COVID-19 Mortality

Review·

May 13, 2026

Ultra-Processed Foods Raise Heart Disease Risk by Up to 65%, Major European Report Finds

Ultra-Processed Foods Raise Heart Disease Risk by Up to 65%, Major European Report Finds

Press·

May 12, 2026

Dr. Kentaro Fujita Reveals the Science of Self-Control and Beating Procrastination

Dr. Kentaro Fujita Reveals the Science of Self-Control and Beating Procrastination

Podcast·

May 12, 2026

Naked Mole Rat Longevity Gene Transferred to Mice Extends Their Lifespan

Naked Mole Rat Longevity Gene Transferred to Mice Extends Their Lifespan

Press·

May 11, 2026

HDAC Inhibitor Plus Checkpoint Blocker Tested in Advanced Lung Cancer Trial

HDAC Inhibitor Plus Checkpoint Blocker Tested in Advanced Lung Cancer Trial

Trial·

May 7, 2026

Low-Dose Ipilimumab Plus Pembrolizumab Targets Melanoma Brain Metastases

Low-Dose Ipilimumab Plus Pembrolizumab Targets Melanoma Brain Metastases

Trial·

May 7, 2026

FDA Grants Expanded Approval to Zongertinib for HER2-Mutant Lung Cancer

FDA Grants Expanded Approval to Zongertinib for HER2-Mutant Lung Cancer

Drug Approval·

May 6, 2026

FDA Approves Four Neurological Drugs Targeting Alzheimer's, Glioma, and Rare Disease

FDA Approves Four Neurological Drugs Targeting Alzheimer's, Glioma, and Rare Disease

Drug Approval·

May 5, 2026

Centenarians Defy Immune Aging Through Unique Inflammatory Control Mechanisms

Centenarians Defy Immune Aging Through Unique Inflammatory Control Mechanisms

Review·

April 28, 2026

Why Some 80-Year-Olds Have the Memory of 50-Year-Olds — Scientists Finally Explain

Why Some 80-Year-Olds Have the Memory of 50-Year-Olds — Scientists Finally Explain

Press·

April 24, 2026

Anti-Amyloid Alzheimer's Drugs Show Trivial Cognitive Benefit With Real Brain Bleed Risk

Anti-Amyloid Alzheimer's Drugs Show Trivial Cognitive Benefit With Real Brain Bleed Risk

Review·

April 20, 2026

FDA Approves Zongertinib for HER2-Mutant Lung Cancer in Landmark Targeted Therapy Win

FDA Approves Zongertinib for HER2-Mutant Lung Cancer in Landmark Targeted Therapy Win

Drug Approval·

April 20, 2026

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Latest Summaries

Fresh from academic journals, YouTube, podcasts, and other sources

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FTO Enzyme Drives Colorectal Cancer Drug Resistance Through Iron Metabolism Control
Longevity & Aging

FTO Enzyme Drives Colorectal Cancer Drug Resistance Through Iron Metabolism Control

A key m6A RNA modifier enables colorectal cancer cells to resist chemotherapy by stabilizing a transcription factor that regulates iron homeostasis.

Research Paper
May 18, 2026 0
Alpha-Ketoglutarate Reverses Cartilage Damage in Osteoarthritis via Epigenetic Reprogramming
Longevity & Aging

Alpha-Ketoglutarate Reverses Cartilage Damage in Osteoarthritis via Epigenetic Reprogramming

αKG supplementation restores glutamine metabolism and halts cartilage destruction in OA models through H3K27me3 demethylation.

Research Paper
May 18, 2026 0
Coffee and Blood Pressure: What the Science Actually Says
Nutrition & Diet

Coffee and Blood Pressure: What the Science Actually Says

Large studies show moderate coffee drinking doesn't raise hypertension risk — and may even support healthier blood vessels.

Press Release
May 18, 2026 0
Seven Days of Fasting Triggers Dramatic Body-Wide Changes After Day Three
Nutrition & Diet

Seven Days of Fasting Triggers Dramatic Body-Wide Changes After Day Three

A proteomics study tracking 3,000 blood proteins reveals fasting's deepest benefits emerge only after 72 hours without food.

Press Release
May 18, 2026 0
Melatonin Restores Brain Waste Clearance Damaged by Chronic Sleep Loss
Sleep & Recovery

Melatonin Restores Brain Waste Clearance Damaged by Chronic Sleep Loss

New research reveals melatonin rescues the brain's glymphatic system after sleep restriction by restoring a critical water channel protein.

Research Paper
May 18, 2026 0
Multiple Sclerosis Accelerates Immune Aging Across Multiple Biological Markers
Autoimmune & Arthritis

Multiple Sclerosis Accelerates Immune Aging Across Multiple Biological Markers

A multi-biomarker study finds pwMS show accelerated thymic involution, senescent T cell expansion, and neuroinflammation linked to aging.

Research Paper
May 18, 2026 0
New Macrocyclic Peptides Selectively Kill Chemotherapy-Resistant Lung Cancer Cells
Cancer Research

New Macrocyclic Peptides Selectively Kill Chemotherapy-Resistant Lung Cancer Cells

Orally bioavailable cyclin A/B RxL inhibitors exploit a cell-cycle vulnerability in small-cell lung cancer and other G1-S-checkpoint-deficient tumors.

Research Paper
May 18, 2026 0
Maternal Diabetes Raises Offspring Cardiovascular Disease Risk by Up to 29%
Heart Health

Maternal Diabetes Raises Offspring Cardiovascular Disease Risk by Up to 29%

A Swedish cohort of 4.3 million found maternal diabetes during pregnancy significantly increases offspring CVD risk, with pregestational diabetes driving the highest hazard.

Research Paper
May 18, 2026 0
Newly Discovered Axonic Spines Rewire How Neurons Fire Action Potentials
Brain Health

Newly Discovered Axonic Spines Rewire How Neurons Fire Action Potentials

A surprising structural feature on axon initial segments lets excitatory synapses jump-start neuron firing and redirect brain circuit information flow.

Research Paper
May 18, 2026 0
Cancer's Growth Protein MYC Found to Secretly Repair Chemo-Damaged DNA
Cancer Research

Cancer's Growth Protein MYC Found to Secretly Repair Chemo-Damaged DNA

MYC protein doesn't just fuel tumor growth — it also repairs DNA damage from chemotherapy, revealing a key resistance mechanism.

Press Release
May 17, 2026 0
30 Minutes of Intense Exercise Per Week Can Cut Disease Risk by Half
Brain Health

30 Minutes of Intense Exercise Per Week Can Cut Disease Risk by Half

Norwegian researchers say short bursts of high-intensity effort just 4.5 minutes daily dramatically improve cardiovascular fitness and lifespan.

Press Release
May 17, 2026 0
Base Editing Corrects Rare Immune Disorder With Platform-Specific Safety Tradeoffs
Regenerative Medicine

Base Editing Corrects Rare Immune Disorder With Platform-Specific Safety Tradeoffs

Cytosine base editing achieved 62–89% efficiency fixing a hyperinflammatory disease gene, but revealed distinct genotoxicity risks across cell types.

Research Paper
May 17, 2026 0
How Aging T Cells Destroy Your Gut Barrier and Fuel Chronic Inflammation
Gut & Microbiome

How Aging T Cells Destroy Your Gut Barrier and Fuel Chronic Inflammation

Age-related shifts in intestinal T cell populations may silently erode gut barrier function, accelerating the chronic inflammation that drives aging diseases.

Review
May 17, 2026 0
Teplizumab Approval Drives 90% Surge in Type 1 Diabetes Autoantibody Screening
Metabolic Health

Teplizumab Approval Drives 90% Surge in Type 1 Diabetes Autoantibody Screening

FDA approval of the first T1D delay drug nearly doubled islet autoantibody testing, but critical gaps remain in screening healthy children.

Research Paper
May 17, 2026 0
Genetic Testing for Pituitary Tumors Gets a Major Update
Hormones

Genetic Testing for Pituitary Tumors Gets a Major Update

A new clinical review maps both established and emerging germline genes behind pituitary adenomas, reshaping how clinicians screen and counsel patients.

Research Paper
May 17, 2026 0
New CSF Biomarker Fragment Could Transform Narcolepsy Type 1 Diagnosis
Sleep & Recovery

New CSF Biomarker Fragment Could Transform Narcolepsy Type 1 Diagnosis

A truncated orexin-A fragment outperforms full-length hypocretin-1 in distinguishing narcolepsy type 1 patients from controls.

Research Paper
May 17, 2026 0
Exercise Rewires Sarcopenia Biomarkers From Inflammation to Muscle Renewal
Exercise & Fitness

Exercise Rewires Sarcopenia Biomarkers From Inflammation to Muscle Renewal

A systematic review of RCTs reveals how resistance training reshapes cytokines, growth factors, and emerging exerkines to combat age-related muscle loss.

Research Paper
May 16, 2026 0
How Inflammaging Drives Age-Related Obesity in Cats — and What It Reveals About Human Aging
Metabolic Health

How Inflammaging Drives Age-Related Obesity in Cats — and What It Reveals About Human Aging

A new review links feline age-related obesity to SASP-driven chronic inflammation, offering translational insights for human metabolic disease.

Research Paper
May 16, 2026 0
Low-Protein Diet Shields the Aging Heart by Activating Cellular Cleanup Machinery
Heart Health

Low-Protein Diet Shields the Aging Heart by Activating Cellular Cleanup Machinery

In obese middle-aged mice, reducing dietary protein—without cutting calories—reversed cardiac inflammation and remodeling via AMPK-ULK1 mitophagy.

Research Paper
May 16, 2026 0
Hybrid Prenatal Exercise Program Eliminates Macrosomia Risk in RCT
Exercise & Fitness

Hybrid Prenatal Exercise Program Eliminates Macrosomia Risk in RCT

Pregnant women in a supervised hybrid exercise program had zero cases of macrosomia vs. 7.3% in usual care controls.

Research Paper
May 16, 2026 0
Biogen's Anti-Tau Alzheimer's Drug Misses Phase 2 But Shows Hints of Promise
Regenerative Medicine

Biogen's Anti-Tau Alzheimer's Drug Misses Phase 2 But Shows Hints of Promise

BIIB080 failed its primary endpoint in Phase 2, yet Biogen sees potential signals worth pursuing in the fight against Alzheimer's tau tangles.

Press Release
May 15, 2026 0
Single Amino Acid Difference Reveals How SARS-CoV-2 Evades Human Immunity
Autoimmune & Arthritis

Single Amino Acid Difference Reveals How SARS-CoV-2 Evades Human Immunity

A comparative protein interaction map of SARS-CoV-2 and its bat progenitor uncovers the molecular switch behind immune evasion and species barriers.

Research Paper
May 15, 2026 0
Vaginal Yeast Supercharges Group B Strep Infections Through Nutrient Exchange
Gut & Microbiome

Vaginal Yeast Supercharges Group B Strep Infections Through Nutrient Exchange

Candida albicans and Group B Streptococcus form a dangerous partnership in the vaginal tract, boosting bacterial virulence and antibiotic resistance.

Research Paper
May 15, 2026 0
Bilateral Adrenal Tumors That Appear Separately Signal Higher Cancer Risk
Hormones

Bilateral Adrenal Tumors That Appear Separately Signal Higher Cancer Risk

A 1,035-patient Mayo Clinic study finds asynchronous bilateral adrenal masses carry double the malignancy rate of simultaneous presentations.

Research Paper
May 13, 2026 0

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