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Breast Milk Sugar Plus Bifidobacteria Reshapes Infant Gut and Prevents Eczema in Mice
2'-FL prebiotics combined with cross-feeding bifidobacteria corrected dysbiotic infant gut microbiota and blocked atopic dermatitis via retinol metabolism activation.
Milk Sugar Plus Infant Probiotic Team Up to Crush Gut Inflammation
3'-Sialyllactose and B. infantis synergistically reduced colitis severity by boosting SCFA-producing gut bacteria through cross-feeding mechanisms.
New Protein-Degrading Chimera Breaks Resistance to Lung Cancer Drug Osimertinib
A CXCR7-targeting chimera selectively degrades mutant EGFR proteins, resensitizing triple-mutant lung cancer cells to osimertinib in lab and animal models.
When You Eat Carbs Around Exercise Changes Morning Glucose Tolerance and Fat Burning
A randomized trial in male cyclists shows post-exercise carb intake worsens next-morning glucose tolerance but boosts metabolic flexibility compared to pre-exercise carbs.
AI Model Predicts Single-Cell Protein Levels Directly from Gene Expression Data
A new large generative AI model infers single-cell proteomes from transcriptomes, unlocking richer disease and aging biology at lower cost.
Cells Share Mitochondria to Fight Aging, Disease and Cancer Resistance
A comprehensive review reveals how cells donate mitochondria to rescue failing neighbors — with profound implications for aging, neurodegeneration, and cancer therapy.
Immune Antibodies Actively Reshape Adult Brain Circuits by Pruning Overactive Synapses
New research reveals antibodies guide immune cells to eliminate hyperactive synaptic connections, remodeling adult brain circuitry in real time.
Gut Bacteria and Blood Proteins Predict Who Gains Fitness From HIIT in Prediabetes
Multi-omics analysis reveals gut microbiome and proteomic signatures that explain why some men with prediabetes gain far more VO2peak from HIIT than others.
Five Sleep Dimensions Linked to Cognitive Performance in Aging Adults
A large multi-ethnic study finds EEG sleep microstructure and sleep continuity independently predict cognitive performance and decline over time.
Fiber Is the Key Nutrient That Lets Beneficial Gut Worms Fight Inflammation
New research shows dietary fiber determines whether therapeutic intestinal worms reduce inflammation or go dormant and useless.
How Hypothalamic Dysfunction Drives Aging, Hormonal Decline and Metabolic Disease
A comprehensive review of hypothalamic anatomy and function reveals how disruption of this master regulator accelerates aging and disease.
Prenatal Vitamins A, C, D and E Show No Effect on Child Type 1 Diabetes Risk
A large Norwegian cohort of 85,000 children finds no link between maternal vitamin intake during pregnancy and offspring type 1 diabetes risk.
Natural Compound Spinosin Fights Postmenopausal Bone Loss via Nrf2 Antioxidant Pathway
Spinosin activates the Nrf2/HO-1 antioxidant pathway to reduce oxidative stress, restore mitochondrial function, and rebuild bone in ovariectomized rats.
How Vitamins A, C, E, K and B Vitamins Orchestrate Bone Fracture Healing
A comprehensive review reveals how specific vitamins regulate bone repair through immune, metabolic, and epigenetic pathways — with dose and timing mattering critically.
Atrial Fibrillation Is Now a Modifiable Disease — Not an Inevitable Part of Aging
New evidence repositions risk-factor management as the fourth pillar of AF care, showing aging and lifestyle factors drive the condition through distinct, treatable mechanisms.
Pre-Surgery Fitness Level Doesn't Change Who Benefits From Cardiac Rehab
Respiratory rehab before and after heart valve surgery cuts pneumonia risk regardless of baseline cardiorespiratory fitness.
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100 Is the New 30
How Playing the Symphony of Longevity Will Enable Us to Live Young for a Lifetime — Jeffrey Gladden, MD, FACC















