4932 articles
A key m6A RNA modifier enables colorectal cancer cells to resist chemotherapy by stabilizing a transcription factor that regulates iron homeostasis.
αKG supplementation restores glutamine metabolism and halts cartilage destruction in OA models through H3K27me3 demethylation.
A landmark review reveals why aging immune systems lose the ability to clear senescent cells — and how new therapies could restore this critical defense.
A landmark NIH-funded consortium is building the first reference atlas of somatic mutations across healthy human tissues to decode aging and disease.
A novel mass spectrometry method maps 482,000 protein-metabolite relationships, revealing how LRRC58 governs cysteine catabolism and hepatic cholesterol.
New research reveals cholecystectomy reshapes gut bacteria and bile acids, suppressing FXR signaling and accelerating colorectal tumor growth.
New research shows taurine suppresses p53-driven senescence in pancreatic β-cells, offering a potential strategy to preserve insulin secretion with age.
A bile acid found in blood predicts and treats obesity-induced endothelial dysfunction through a newly discovered FXR-ATF4 metabolic axis.
New research shows that stripping DNA methylation from cancer cells—without causing DNA damage—drives them into irreversible cellular senescence.
A novel SQSTM1-mediated selective autophagy pathway degrades p16 and p21, reducing cellular senescence in degenerative mitral valve disease.
New research finds DSAD brains carry twice the iron of controls, triggering lipid peroxidation and cell death pathways linked to ferroptosis.
A 2025 review reveals how two sulfur-based amino acids act as master regulators of cellular redox balance and age-related decline.
