Triphala Plus High-Intensity Exercise Shows Promise for Immune Function and Antioxidants

This completed randomized controlled trial investigated whether triphala supplementation combined with high-intensity interval training could enhance immune function and reduce oxidative stress better than either intervention alone. Triphala, a traditional Ayurvedic blend of three fruits, has shown antioxidant properties in preliminary studies.

Researchers at Burapha University enrolled 141 healthy men and women aged 18-59 and randomly assigned them to four groups over 8 weeks. The control group received placebo capsules, while experimental groups received either 1,000mg daily triphala (500mg before breakfast and dinner, 5 days weekly), HIIT leg cycling (28 minutes, 3 days weekly), or both interventions combined.

The study measured critical immune system markers including interferon-gamma and tumor necrosis factor-alpha, which indicate immune activation and inflammation levels. Oxidative stress was assessed through malondialdehyde and protein carbonyl levels, which reflect cellular damage from free radicals. Safety monitoring included liver enzyme ALT and creatinine levels to detect potential toxicity.

This trial addresses a significant gap in longevity research by rigorously testing whether ancient herbal wisdom combined with modern exercise science could optimize two key aging factors: immune function and oxidative damage. Both decline with age and contribute to increased disease risk and reduced healthspan.

The combination approach is particularly relevant for health optimization, as exercise alone can temporarily increase oxidative stress, while antioxidant compounds like those in triphala might help mitigate this effect while preserving exercise benefits. Results could inform evidence-based protocols for maintaining robust immune function and cellular health throughout the aging process.