Longevity & Aging892 Plasma Proteins Linked to Heart Disease Risk in 53,000-Person Study
Researchers analyzed 2,920 plasma proteins in 53,026 UK Biobank participants over 14 years, identifying 892 unique proteins significantly associated with 13 cardiovascular disease outcomes. Key findings include NT-proBNP as the strongest predictor of atrial fibrillation and GDF15 for heart failure. Mendelian randomization confirmed 225 proteins causally linked to CVDs, with LPA showing the strongest coronary artery disease association. A machine-learning prediction model achieved an AUC of 0.86 for abdominal aortic aneurysm. Mediation analysis revealed that modifiable risk factors like smoking and BMI mediate many protein-CVD relationships, pointing toward actionable prevention targets.
