Longevity & AgingAging and Atherosclerosis Create Vicious Cycle That Accelerates Both Diseases
This comprehensive review reveals that aging and atherosclerosis form a bidirectional, self-reinforcing cycle. Aging promotes atherosclerosis through endothelial dysfunction, immune senescence, and mitochondrial damage, while atherosclerosis accelerates systemic aging via chronic inflammation and tissue hypoxia. Both processes share key mechanisms including cellular senescence, oxidative stress, and stem cell exhaustion. Understanding these interconnected pathways opens new therapeutic opportunities targeting both cardiovascular disease and aging simultaneously through interventions like senolytics and NAD+ supplementation.
