A $6.2 million grant from the National Institute on Aging is funding a five-year project at Case Western Reserve University that uses artificial intelligence to rethink Alzheimer's disease from the ground up. Rather than focusing on amyloid plaques — the visible brain damage that current drugs target — researchers are analyzing over 1,800 genes linked to Alzheimer's to identify which ones actually drive the disease. AI will cross-reference massive genetic datasets from two of the world's largest Alzheimer's genomics initiatives, spanning diverse populations. The goal is to produce a validated list of drug targets for the next generation of therapies, shifting the field from late-stage treatment toward early genetic risk detection and prevention.
