Longevity & AgingBile Acid Lithocholic Acid Mimics Anti-Aging Benefits of Caloric Restriction
Scientists discovered that lithocholic acid (LCA), a bile acid elevated during caloric restriction, can independently reproduce the anti-aging effects of reduced calorie intake. Testing in mice, worms, and flies showed LCA activates AMPK signaling, improves muscle function, and extends both lifespan and healthspan. This breakthrough identifies a specific molecule responsible for caloric restriction's benefits, potentially enabling targeted interventions without dietary restrictions. The findings suggest LCA supplementation could offer a practical approach to achieving longevity benefits.
