Longevity & AgingDNA Methylation Clocks Can Predict Your Biological Age and Time to Death
Dr. Steve Horvath, UCLA professor and creator of epigenetic aging clocks, discusses how DNA methylation patterns can accurately predict biological age across different tissues and species. His algorithms, including the Horvath clock, PhenoAge, and GrimAge, analyze chemical modifications to DNA that change with age. These clocks can predict mortality risk and healthspan among people of the same chronological age. The episode covers how genetics influence aging rates, differences between second-generation clocks, and interventions that may slow epigenetic aging. Horvath explains whether epigenetic changes cause aging or result from it, and discusses research showing vitamin D and omega-3 fatty acids may reverse or slow these aging markers.
