Longevity & AgingDNA Repair Enzymes Control T Cell Function and Immune Aging
This review examines how TET and TDG enzymes control DNA methylation patterns in T cells, influencing immune function and aging. These proteins work together to remove methyl groups from DNA, allowing genes to be turned on or off. When TET proteins malfunction, it leads to inflammation, cancer, and clonal hematopoiesis - a condition linked to aging where certain immune cells multiply abnormally. The research highlights how epigenetic changes in T cells contribute to age-related immune dysfunction and disease.
