Nutrition & DietDr Federica Amati Breaks Down GLP-1 Biology and How to Optimize Appetite Naturally
In this episode of The Proof, Simon Hill interviews Dr Federica Amati, Head Nutritionist at ZOE and author of The Appetite Reset, about the biology of appetite and how GLP-1 medications interact with natural hunger systems. They cover three distinct types of hunger — homeostatic, hedonic, and microbiota-driven — and why conflating them leads to poor dietary decisions. Dr Amati explains why natural GLP-1 peptides last only minutes while drug versions last days, and what that means for real-world use. Key practical recommendations include maintaining 30g of daily fiber even during caloric restriction on medication, targeting 1.2–1.6g of protein per kilogram of body weight, and performing resistance training three times weekly to preserve muscle and bone mass. The episode also addresses the science of weight stigma and why obesity cannot be reduced to a lifestyle choice.
