Longevity & AgingFlavonoids Fight Aging by Taming Oxidative Stress and Chronic Inflammation
Flavonoids — polyphenolic compounds abundant in fruits, vegetables, and grains — are emerging as powerful modulators of oxidative stress and chronic inflammation, two root drivers of aging-related diseases. This comprehensive 2025 review examines six major dietary flavonoid subgroups, including quercetin, epicatechin, and genistein, detailing how their molecular structure enables them to chelate metals, scavenge reactive oxygen species, and regulate inflammatory cytokines like IL-1β, IL-6, and TNF-α. They also activate protective pathways such as Nrf2 and modulate Bcl-2 proteins to induce apoptosis. Evidence from epidemiological studies supports their role in reducing risk across cardiovascular, neurodegenerative, autoimmune, and oncological conditions, positioning flavonoids as promising adjuncts to conventional therapies.
