Longevity & Aging

Immune System Aging Drives Multiple Age-Related Diseases Through Chronic Inflammation

As we age, our immune system undergoes significant changes that contribute to multiple age-related diseases. This comprehensive review examines how aging affects both innate and adaptive immune cells, leading to chronic low-grade inflammation called 'inflammaging.' The research highlights how these immune changes particularly impact kidney and autoimmune diseases, while identifying tertiary lymphoid structures as key markers of immune aging that could serve as therapeutic targets for treating age-related conditions.