Gut & Microbiome

MIT Discovers Gut Protein That Traps and Kills Dangerous Bacteria

MIT scientists have discovered that intelectin-2, a naturally occurring gut protein, acts as a powerful two-layer defense system against harmful bacteria. The protein strengthens the protective mucus lining of the gastrointestinal tract while simultaneously trapping and killing dangerous microbes that attempt to breach this barrier. By binding to sugar molecules on both mucus and bacterial surfaces, intelectin-2 can neutralize threats including antibiotic-resistant bacteria. This discovery could lead to new treatments for gut infections and help restore intestinal health in conditions like inflammatory bowel disease, offering hope for people with compromised gut barriers.