Longevity & Aging

Sarcosine Supplement Shows Promise for Preventing Age-Related Muscle Loss

Researchers analyzed blood samples from over 1,000 people and found that sarcosine, an amino acid derivative, decreases with age and in people with sarcopenia (age-related muscle loss). Mouse studies showed that sarcosine supplementation helps maintain muscle mass, promotes fat burning, and enhances muscle repair by activating anti-inflammatory immune cells called macrophages. The compound works through the GCN2 signaling pathway to reduce chronic inflammation and improve insulin sensitivity, both crucial for preventing muscle wasting in older adults.