SupplementsUrolithin A vs Spermidine: Which Longevity Compound Works Better for Cellular Health
Scientists compared two popular longevity compounds - urolithin A and spermidine - finding they work through different cellular pathways. Urolithin A, derived from pomegranates and berries, specifically targets mitochondrial cleanup (mitophagy) to improve muscle function and energy production. Spermidine, found in wheat germ and aged cheese, triggers broader cellular cleanup (autophagy) for cardiovascular and brain health. While both compounds safely promote anti-aging effects, urolithin A appears better for mitochondrial health while spermidine offers more comprehensive metabolic benefits. This suggests combining both supplements or choosing based on specific health goals may optimize longevity outcomes.
