Longevity & AgingYour Gut Microbiome May Be the Key to Living Longer and Healthier
A comprehensive 2025 review in Genome Medicine examines how the gut microbiome changes across the human lifespan and how those changes—termed 'biome-aging'—drive age-related diseases. The authors introduce the concept of biome-aging to describe the progressive loss of beneficial gut bacteria, rise of harmful pathobionts, and increased intestinal permeability that accompany aging. They detail how factors like polypharmacy, poor diet, physical inactivity, and hormonal shifts accelerate this microbial decline. The review evaluates emerging microbiome-based therapies—including probiotics, prebiotics, postbiotics, fiber-rich diets, polyphenols, and fecal microbiota transplantation—as promising tools to restore gut balance, reduce chronic inflammation, and promote healthy aging and longevity.
